Drug interactions
Aprepitant + Norgestrel
Severity: Moderate
Aprepitant and Norgestrel: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Aprepitant is a moderate CYP3A4 inhibitor that may modestly raise norgestrel concentrations. However, aprepitant is also reported to lower hormonal contraceptive exposure through induction of other enzymes, so contraceptive reliability may be affected during and after treatment.
What this interaction means in plain words
Aprepitant and Norgestrel can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Aprepitant belongs to Gastrointestinal Tract; Norgestrel belongs to Endocrine.
Why it happens
Aprepitant inhibits CYP3A4 (and may induce CYP2C9/other pathways), altering the metabolism of norgestrel.
What to do
Advise an additional non-hormonal contraceptive method during aprepitant treatment and for about one month after the last dose. Watch for progestogen-related adverse effects.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Aprepitant
- Aprepitant + Lomitapide Contraindicated
- Aprepitant + Pimozide Contraindicated
- Aprepitant + Avapritinib Major
- Aprepitant + Bosutinib Major
- Aprepitant + Carbamazepine Major
- Aprepitant + Cobicistat Major
Other interactions of Norgestrel
- Amobarbital + Norgestrel Major
- Apalutamide + Norgestrel Major
- Bosentan + Norgestrel Major
- Carbamazepine + Norgestrel Major
- Efavirenz + Norgestrel Major
- Enzalutamide + Norgestrel Major
Frequently asked questions
Can I take Aprepitant with Norgestrel?
MediHelp rates the interaction as moderate. Aprepitant and Norgestrel can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Aprepitant is a moderate CYP3A4 inhibitor that may modestly raise norgestrel concentrations. However, aprepitant is also reported to lower hormonal contraceptive exposure through induction of other enzymes, so contraceptive reliability may be affected during and after treatment.
How serious is the interaction between Aprepitant and Norgestrel?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Advise an additional non-hormonal contraceptive method during aprepitant treatment and for about one month after the last dose. Watch for progestogen-related adverse effects.
What other medicines interact with Aprepitant?
MediHelp also lists interactions of Aprepitant with, for example, Lomitapide, Pimozide, Avapritinib. The full list is on the Aprepitant page.
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