Drug interactions
Aprepitant + Pazopanib
Severity: Moderate
Aprepitant and Pazopanib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Aprepitant is a moderate CYP3A4 inhibitor and may increase pazopanib exposure. This could heighten the risk of hepatotoxicity, hypertension and QT prolongation.
What this interaction means in plain words
Aprepitant and Pazopanib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Aprepitant belongs to Gastrointestinal Tract; Pazopanib belongs to Oncology.
Why it happens
Inhibition of CYP3A4-mediated pazopanib metabolism by aprepitant.
What to do
Monitor liver function, blood pressure and ECG, and reduce the pazopanib dose if toxicity develops. Consider a different antiemetic if prolonged use is needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Aprepitant
- Aprepitant + Lomitapide Contraindicated
- Aprepitant + Pimozide Contraindicated
- Aprepitant + Avapritinib Major
- Aprepitant + Bosutinib Major
- Aprepitant + Carbamazepine Major
- Aprepitant + Cobicistat Major
Other interactions of Pazopanib
- Adagrasib + Pazopanib Major
- Amiodarone + Pazopanib Major
- Amisulpride + Pazopanib Major
- Amobarbital + Pazopanib Major
- Anagrelide + Pazopanib Major
- Apalutamide + Pazopanib Major
Frequently asked questions
Can I take Aprepitant with Pazopanib?
MediHelp rates the interaction as moderate. Aprepitant and Pazopanib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Aprepitant is a moderate CYP3A4 inhibitor and may increase pazopanib exposure. This could heighten the risk of hepatotoxicity, hypertension and QT prolongation.
How serious is the interaction between Aprepitant and Pazopanib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor liver function, blood pressure and ECG, and reduce the pazopanib dose if toxicity develops. Consider a different antiemetic if prolonged use is needed.
What other medicines interact with Aprepitant?
MediHelp also lists interactions of Aprepitant with, for example, Lomitapide, Pimozide, Avapritinib. The full list is on the Aprepitant page.
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