Drug interactions
Aprepitant + Pioglitazone
Severity: Minor
Aprepitant and Pioglitazone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pioglitazone is metabolised mainly by CYP2C8 with a minor CYP3A4 contribution, so aprepitant is unlikely to change its exposure meaningfully.
What this interaction means in plain words
Aprepitant and Pioglitazone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Aprepitant belongs to Gastrointestinal Tract; Pioglitazone belongs to Endocrine.
Why it happens
Weak effect through partial CYP3A4 inhibition of a minor pioglitazone pathway.
What to do
No action is needed beyond routine glucose monitoring.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Aprepitant
- Aprepitant + Lomitapide Contraindicated
- Aprepitant + Pimozide Contraindicated
- Aprepitant + Avapritinib Major
- Aprepitant + Bosutinib Major
- Aprepitant + Carbamazepine Major
- Aprepitant + Cobicistat Major
Other interactions of Pioglitazone
Frequently asked questions
Can I take Aprepitant with Pioglitazone?
MediHelp rates the interaction as minor. Aprepitant and Pioglitazone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Pioglitazone is metabolised mainly by CYP2C8 with a minor CYP3A4 contribution, so aprepitant is unlikely to change its exposure meaningfully.
How serious is the interaction between Aprepitant and Pioglitazone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No action is needed beyond routine glucose monitoring.
What other medicines interact with Aprepitant?
MediHelp also lists interactions of Aprepitant with, for example, Lomitapide, Pimozide, Avapritinib. The full list is on the Aprepitant page.
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