Drug interactions
Aprepitant + Tadalafil
Severity: Moderate
Aprepitant and Tadalafil: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tadalafil is cleared by CYP3A4, so aprepitant may increase its exposure. This may cause more headache, flushing, hypotension and dyspepsia.
What this interaction means in plain words
Aprepitant and Tadalafil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Aprepitant belongs to Gastrointestinal Tract; Tadalafil belongs to Genitourinary.
Why it happens
Aprepitant inhibits CYP3A4 metabolism of tadalafil.
What to do
Monitor blood pressure and tolerability and consider a lower tadalafil dose; avoid nitrates.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Aprepitant
- Aprepitant + Lomitapide Contraindicated
- Aprepitant + Pimozide Contraindicated
- Aprepitant + Avapritinib Major
- Aprepitant + Bosutinib Major
- Aprepitant + Carbamazepine Major
- Aprepitant + Cobicistat Major
Other interactions of Tadalafil
- Amyl nitrite + Tadalafil Contraindicated
- Isosorbide dinitrate + Tadalafil Contraindicated
- Isosorbide mononitrate + Tadalafil Contraindicated
- Nitroglycerin po + Tadalafil Contraindicated
- Nitroglycerin rectal + Tadalafil Contraindicated
- Nitroglycerin sublingual + Tadalafil Contraindicated
Frequently asked questions
Can I take Aprepitant with Tadalafil?
MediHelp rates the interaction as moderate. Aprepitant and Tadalafil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Tadalafil is cleared by CYP3A4, so aprepitant may increase its exposure. This may cause more headache, flushing, hypotension and dyspepsia.
How serious is the interaction between Aprepitant and Tadalafil?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and tolerability and consider a lower tadalafil dose; avoid nitrates.
What other medicines interact with Aprepitant?
MediHelp also lists interactions of Aprepitant with, for example, Lomitapide, Pimozide, Avapritinib. The full list is on the Aprepitant page.
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