Drug interactions
Aprepitant + Trabectedin
Severity: Moderate
Aprepitant and Trabectedin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Trabectedin is metabolized primarily by CYP3A4, so aprepitant may increase its exposure and the risk of hepatotoxicity, myelosuppression and rhabdomyolysis.
What this interaction means in plain words
Aprepitant and Trabectedin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Aprepitant belongs to Gastrointestinal Tract; Trabectedin belongs to Oncology.
Why it happens
Aprepitant inhibits CYP3A4, reducing trabectedin metabolism.
What to do
Monitor liver enzymes, CPK and blood counts closely. Consider an alternative antiemetic if toxicity develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Aprepitant
- Aprepitant + Lomitapide Contraindicated
- Aprepitant + Pimozide Contraindicated
- Aprepitant + Avapritinib Major
- Aprepitant + Bosutinib Major
- Aprepitant + Carbamazepine Major
- Aprepitant + Cobicistat Major
Other interactions of Trabectedin
Frequently asked questions
Can I take Aprepitant with Trabectedin?
MediHelp rates the interaction as moderate. Aprepitant and Trabectedin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Trabectedin is metabolized primarily by CYP3A4, so aprepitant may increase its exposure and the risk of hepatotoxicity, myelosuppression and rhabdomyolysis.
How serious is the interaction between Aprepitant and Trabectedin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor liver enzymes, CPK and blood counts closely. Consider an alternative antiemetic if toxicity develops.
What other medicines interact with Aprepitant?
MediHelp also lists interactions of Aprepitant with, for example, Lomitapide, Pimozide, Avapritinib. The full list is on the Aprepitant page.
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