Drug interactions
Aprepitant + Triamcinolone
Severity: Moderate
Aprepitant and Triamcinolone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Aprepitant is a moderate CYP3A4 inhibitor and can raise exposure to triamcinolone, which is partly cleared by CYP3A4. This may increase corticosteroid effects such as hyperglycemia, fluid retention and adrenal suppression, mainly with repeated dosing.
What this interaction means in plain words
Aprepitant and Triamcinolone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Aprepitant belongs to Gastrointestinal Tract; Triamcinolone belongs to Endocrine.
Why it happens
Inhibition of CYP3A4-mediated metabolism of triamcinolone by aprepitant.
What to do
Watch for signs of corticosteroid excess during repeated or prolonged use. Consider reducing the triamcinolone dose if systemic effects appear.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Triamcinolone
- Smallpox vaccine live + Triamcinolone Contraindicated
- Triamcinolone + Zoster vaccine live Contraindicated
- Adenovirus types 4 and 7 live + Triamcinolone Major
- Aldesleukin + Triamcinolone Major
- Atazanavir + Triamcinolone Major
- Axicabtagene ciloleucel + Triamcinolone Major
Other interactions of Aprepitant
- Aprepitant + Lomitapide Contraindicated
- Aprepitant + Pimozide Contraindicated
- Aprepitant + Avapritinib Major
- Aprepitant + Bosutinib Major
- Aprepitant + Carbamazepine Major
- Aprepitant + Cobicistat Major
Frequently asked questions
Can I take Aprepitant with Triamcinolone?
MediHelp rates the interaction as moderate. Aprepitant and Triamcinolone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Aprepitant is a moderate CYP3A4 inhibitor and can raise exposure to triamcinolone, which is partly cleared by CYP3A4. This may increase corticosteroid effects such as hyperglycemia, fluid retention and adrenal suppression, mainly with repeated dosing.
How serious is the interaction between Aprepitant and Triamcinolone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Watch for signs of corticosteroid excess during repeated or prolonged use. Consider reducing the triamcinolone dose if systemic effects appear.
What other medicines interact with Triamcinolone?
MediHelp also lists interactions of Triamcinolone with, for example, Smallpox vaccine live, Zoster vaccine live, Adenovirus types 4 and 7 live. The full list is on the Triamcinolone page.
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