Drug interactions
Aprepitant + Vincristine
Severity: Moderate
Aprepitant and Vincristine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Vincristine is metabolised by CYP3A4, which aprepitant inhibits moderately. Higher vincristine exposure could worsen neurotoxicity such as peripheral neuropathy, constipation and ileus. Clinical data are limited and the effect is probably modest.
What this interaction means in plain words
Aprepitant and Vincristine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Aprepitant belongs to Gastrointestinal Tract; Vincristine belongs to Oncology.
Why it happens
Aprepitant inhibits CYP3A4, reducing the metabolism of vincristine.
What to do
Monitor for neuropathy and severe constipation or ileus, especially over repeated cycles. Reduce the vincristine dose or delay treatment if neurotoxicity appears.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Aprepitant
- Aprepitant + Lomitapide Contraindicated
- Aprepitant + Pimozide Contraindicated
- Aprepitant + Avapritinib Major
- Aprepitant + Bosutinib Major
- Aprepitant + Carbamazepine Major
- Aprepitant + Cobicistat Major
Other interactions of Vincristine
- Adenovirus types 4 and 7 live + Vincristine Contraindicated
- Apalutamide + Vincristine Major
- Atazanavir + Vincristine Major
- Ceritinib + Vincristine Major
- Chloramphenicol + Vincristine Major
- Clarithromycin + Vincristine Major
Frequently asked questions
Can I take Aprepitant with Vincristine?
MediHelp rates the interaction as moderate. Aprepitant and Vincristine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Vincristine is metabolised by CYP3A4, which aprepitant inhibits moderately. Higher vincristine exposure could worsen neurotoxicity such as peripheral neuropathy, constipation and ileus. Clinical data are limited and the effect is probably modest.
How serious is the interaction between Aprepitant and Vincristine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for neuropathy and severe constipation or ileus, especially over repeated cycles. Reduce the vincristine dose or delay treatment if neurotoxicity appears.
What other medicines interact with Aprepitant?
MediHelp also lists interactions of Aprepitant with, for example, Lomitapide, Pimozide, Avapritinib. The full list is on the Aprepitant page.
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