Drug interactions
Aprepitant + Vinorelbine
Severity: Moderate
Aprepitant and Vinorelbine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Vinorelbine is metabolised by CYP3A4, and aprepitant is a moderate inhibitor of this enzyme. Exposure may rise, increasing the risk of myelosuppression and neuropathy. Clinical significance is not well defined.
What this interaction means in plain words
Aprepitant and Vinorelbine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Aprepitant belongs to Gastrointestinal Tract; Vinorelbine belongs to Oncology.
Why it happens
Aprepitant inhibits CYP3A4, reducing the metabolic clearance of vinorelbine.
What to do
Monitor neutrophil counts and neurological symptoms during treatment. Adjust the vinorelbine dose for neutropenia or neurotoxicity as per protocol.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Aprepitant
- Aprepitant + Lomitapide Contraindicated
- Aprepitant + Pimozide Contraindicated
- Aprepitant + Avapritinib Major
- Aprepitant + Bosutinib Major
- Aprepitant + Carbamazepine Major
- Aprepitant + Cobicistat Major
Other interactions of Vinorelbine
Frequently asked questions
Can I take Aprepitant with Vinorelbine?
MediHelp rates the interaction as moderate. Aprepitant and Vinorelbine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Vinorelbine is metabolised by CYP3A4, and aprepitant is a moderate inhibitor of this enzyme. Exposure may rise, increasing the risk of myelosuppression and neuropathy. Clinical significance is not well defined.
How serious is the interaction between Aprepitant and Vinorelbine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor neutrophil counts and neurological symptoms during treatment. Adjust the vinorelbine dose for neutropenia or neurotoxicity as per protocol.
What other medicines interact with Aprepitant?
MediHelp also lists interactions of Aprepitant with, for example, Lomitapide, Pimozide, Avapritinib. The full list is on the Aprepitant page.
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