Drug interactions
Arformoterol + Leuprolide
Severity: Moderate
Arformoterol and Leuprolide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Leuprolide may prolong the QT interval, and arformoterol, a long-acting beta2 agonist, can cause hypokalemia, tachycardia and QT changes. The combination may increase the risk of ventricular arrhythmias in patients with cardiac risk factors.
What this interaction means in plain words
Arformoterol and Leuprolide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Arformoterol belongs to Respiratory; Leuprolide belongs to Endocrine.
Why it happens
Additive QT prolongation with beta2-agonist-induced hypokalemia and sympathetic stimulation.
What to do
Monitor ECG and serum potassium in patients with cardiac disease or other QT risk factors. Do not exceed the recommended arformoterol dose.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Arformoterol and Leuprolide, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Leuprolide
- Leuprolide + Pimozide Contraindicated
- Leuprolide + Thioridazine Contraindicated
- Amisulpride + Leuprolide Major
- Arsenic trioxide + Leuprolide Major
- Artemether / lumefantrine + Leuprolide Major
- Disopyramide + Leuprolide Major
Other interactions of Arformoterol
Frequently asked questions
Can I take Arformoterol with Leuprolide?
MediHelp rates the interaction as moderate. Arformoterol and Leuprolide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Leuprolide may prolong the QT interval, and arformoterol, a long-acting beta2 agonist, can cause hypokalemia, tachycardia and QT changes. The combination may increase the risk of ventricular arrhythmias in patients with cardiac risk factors.
How serious is the interaction between Arformoterol and Leuprolide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor ECG and serum potassium in patients with cardiac disease or other QT risk factors. Do not exceed the recommended arformoterol dose.
What other medicines interact with Leuprolide?
MediHelp also lists interactions of Leuprolide with, for example, Pimozide, Thioridazine, Amisulpride. The full list is on the Leuprolide page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
