Drug reference
leuprolide
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Drug class
Endocrine (Pituitary Hormones)
Mechanism of action
When administered continuously, decreases LH and FSH levels by acting as potent inhibitor of gonadotropin secretion; decrease in LH and FSH levels followed by suppression of ovarian and testicular steroidogenesis; testosterone levels reduced to below castrated levels in males Agonist analogue of luteinizing hormone-releasing hormone (LHRH)
Common side effects
- Injection site pain
- Nasopharyngitis
- Headache
- Cough
- Pyrexia
- Emotional lability
Known interactions (6)
- dronedarone + leuprolide Major
- amiodarone + leuprolide Moderate
- anagrelide + leuprolide Moderate
- citalopram + leuprolide Moderate
- escitalopram + leuprolide Moderate
- fluoxetine + leuprolide Moderate
Related conditions
Frequently asked questions
What drug class is leuprolide?
leuprolide belongs to: Endocrine.
How does leuprolide work?
When administered continuously, decreases LH and FSH levels by acting as potent inhibitor of gonadotropin secretion; decrease in LH and FSH levels followed by suppression of ovarian and testicular steroidogenesis; testosterone levels reduced to below castrated levels in males Agonist analogue of luteinizing hormone-releasing hormone (LHRH)
What are the common side effects of leuprolide?
Injection site pain, Nasopharyngitis, Headache, Cough, Pyrexia, Emotional lability
Which drugs interact with leuprolide?
dronedarone, amiodarone, anagrelide, citalopram, escitalopram, fluoxetine
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