Drug interactions
Leuprolide + Pimozide
Severity: Contraindicated
Leuprolide and Pimozide: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Androgen deprivation therapy with leuprolide is associated with QT prolongation, and pimozide strongly prolongs QT. Together the risk of torsades de pointes increases.
What this interaction means in plain words
Leuprolide and Pimozide are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Leuprolide belongs to Endocrine; Pimozide belongs to Central Nervous System.
Why it happens
Additive delayed cardiac repolarization.
What to do
Avoid the combination if possible and use a non-QT-prolonging alternative. If unavoidable, monitor ECG and electrolytes closely.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Pimozide
- Adagrasib + Pimozide Contraindicated
- Amiodarone + Pimozide Contraindicated
- Amisulpride + Pimozide Contraindicated
- Amitriptyline + Pimozide Contraindicated
- Amoxapine + Pimozide Contraindicated
- Anagrelide + Pimozide Contraindicated
Other interactions of Leuprolide
- Leuprolide + Thioridazine Contraindicated
- Amisulpride + Leuprolide Major
- Arsenic trioxide + Leuprolide Major
- Artemether / lumefantrine + Leuprolide Major
- Disopyramide + Leuprolide Major
- Dofetilide + Leuprolide Major
Frequently asked questions
Can I take Leuprolide with Pimozide?
MediHelp rates the interaction as contraindicated. Leuprolide and Pimozide are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Androgen deprivation therapy with leuprolide is associated with QT prolongation, and pimozide strongly prolongs QT. Together the risk of torsades de pointes increases.
How serious is the interaction between Leuprolide and Pimozide?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination if possible and use a non-QT-prolonging alternative. If unavoidable, monitor ECG and electrolytes closely.
What other medicines interact with Pimozide?
MediHelp also lists interactions of Pimozide with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Pimozide page.
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