Drug interactions
Disopyramide + Leuprolide
Severity: Major
Disopyramide and Leuprolide: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Leuprolide may lengthen the QT interval, and disopyramide is a class Ia antiarrhythmic with a known risk of torsades de pointes. Using them together adds to proarrhythmic risk.
What this interaction means in plain words
Disopyramide and Leuprolide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Disopyramide belongs to Cardiovascular; Leuprolide belongs to Endocrine.
Why it happens
Additive QT prolongation from androgen deprivation (leuprolide) and sodium and potassium channel blockade (disopyramide).
What to do
Check a baseline ECG and electrolytes, and monitor the QTc after starting. Consider an alternative to disopyramide or a different form of androgen deprivation therapy if the QTc becomes prolonged.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Leuprolide
- Leuprolide + Pimozide Contraindicated
- Leuprolide + Thioridazine Contraindicated
- Amisulpride + Leuprolide Major
- Arsenic trioxide + Leuprolide Major
- Artemether / lumefantrine + Leuprolide Major
- Dofetilide + Leuprolide Major
Other interactions of Disopyramide
- Amisulpride + Disopyramide Contraindicated
- Desipramine + Disopyramide Contraindicated
- Disopyramide + Dronedarone Contraindicated
- Disopyramide + Itraconazole Contraindicated
- Disopyramide + Ketoconazole Contraindicated
- Disopyramide + Maprotiline Contraindicated
Frequently asked questions
Can I take Disopyramide with Leuprolide?
MediHelp rates the interaction as major. Disopyramide and Leuprolide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Leuprolide may lengthen the QT interval, and disopyramide is a class Ia antiarrhythmic with a known risk of torsades de pointes. Using them together adds to proarrhythmic risk.
How serious is the interaction between Disopyramide and Leuprolide?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check a baseline ECG and electrolytes, and monitor the QTc after starting. Consider an alternative to disopyramide or a different form of androgen deprivation therapy if the QTc becomes prolonged.
What other medicines interact with Leuprolide?
MediHelp also lists interactions of Leuprolide with, for example, Pimozide, Thioridazine, Amisulpride. The full list is on the Leuprolide page.
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