Drug interactions
Amisulpride + Leuprolide
Severity: Major
Amisulpride and Leuprolide: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Androgen deprivation therapy with leuprolide can prolong the QT interval, and amisulpride causes dose-dependent QT prolongation. Combined use raises the risk of torsades de pointes.
What this interaction means in plain words
Amisulpride and Leuprolide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Amisulpride belongs to Central Nervous System; Leuprolide belongs to Endocrine.
Why it happens
Additive QT prolongation through androgen deprivation and direct cardiac repolarization effects.
What to do
Avoid the combination if an alternative exists. Otherwise obtain a baseline ECG, monitor the QTc, and correct potassium and magnesium abnormalities.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Leuprolide
- Leuprolide + Pimozide Contraindicated
- Leuprolide + Thioridazine Contraindicated
- Arsenic trioxide + Leuprolide Major
- Artemether / lumefantrine + Leuprolide Major
- Disopyramide + Leuprolide Major
- Dofetilide + Leuprolide Major
Other interactions of Amisulpride
- Amiodarone + Amisulpride Contraindicated
- Amisulpride + Arsenic trioxide Contraindicated
- Amisulpride + Disopyramide Contraindicated
- Amisulpride + Dofetilide Contraindicated
- Amisulpride + Droperidol Contraindicated
- Amisulpride + Ibutilide Contraindicated
Frequently asked questions
Can I take Amisulpride with Leuprolide?
MediHelp rates the interaction as major. Amisulpride and Leuprolide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Androgen deprivation therapy with leuprolide can prolong the QT interval, and amisulpride causes dose-dependent QT prolongation. Combined use raises the risk of torsades de pointes.
How serious is the interaction between Amisulpride and Leuprolide?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination if an alternative exists. Otherwise obtain a baseline ECG, monitor the QTc, and correct potassium and magnesium abnormalities.
What other medicines interact with Leuprolide?
MediHelp also lists interactions of Leuprolide with, for example, Pimozide, Thioridazine, Arsenic trioxide. The full list is on the Leuprolide page.
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