Drug interactions
Leuprolide + Thioridazine
Severity: Contraindicated
Leuprolide and Thioridazine: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can prolong the QT interval; androgen deprivation therapy such as leuprolide is associated with QT prolongation. Thioridazine causes marked dose-related QTc prolongation and torsades de pointes. Combined use adds to arrhythmia risk.
What this interaction means in plain words
Leuprolide and Thioridazine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Leuprolide belongs to Endocrine; Thioridazine belongs to Central Nervous System.
Why it happens
Additive delayed cardiac repolarization through hERG potassium channel blockade (thioridazine) and hormonal effects on repolarization (leuprolide).
What to do
Avoid the combination; use an antipsychotic with lower QT liability. If unavoidable, get baseline and follow-up ECGs and correct potassium and magnesium.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Thioridazine
- Abiraterone + Thioridazine Contraindicated
- Adagrasib + Thioridazine Contraindicated
- Amiodarone + Thioridazine Contraindicated
- Amisulpride + Thioridazine Contraindicated
- Amitriptyline + Thioridazine Contraindicated
- Amoxapine + Thioridazine Contraindicated
Other interactions of Leuprolide
- Leuprolide + Pimozide Contraindicated
- Amisulpride + Leuprolide Major
- Arsenic trioxide + Leuprolide Major
- Artemether / lumefantrine + Leuprolide Major
- Disopyramide + Leuprolide Major
- Dofetilide + Leuprolide Major
Frequently asked questions
Can I take Leuprolide with Thioridazine?
MediHelp rates the interaction as contraindicated. Leuprolide and Thioridazine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Both drugs can prolong the QT interval; androgen deprivation therapy such as leuprolide is associated with QT prolongation. Thioridazine causes marked dose-related QTc prolongation and torsades de pointes. Combined use adds to arrhythmia risk.
How serious is the interaction between Leuprolide and Thioridazine?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination; use an antipsychotic with lower QT liability. If unavoidable, get baseline and follow-up ECGs and correct potassium and magnesium.
What other medicines interact with Thioridazine?
MediHelp also lists interactions of Thioridazine with, for example, Abiraterone, Adagrasib, Amiodarone. The full list is on the Thioridazine page.
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