Drug interactions
Argatroban + Clarithromycin
Severity: Minor
Argatroban and Clarithromycin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Argatroban is cleared mostly by hepatic metabolism with a small CYP3A4 contribution. Clarithromycin has shown only a limited effect on argatroban exposure, so clinically important bleeding risk from this interaction appears small.
What this interaction means in plain words
Argatroban and Clarithromycin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Argatroban belongs to Cardiovascular; Clarithromycin belongs to Anti Bacterial.
Why it happens
Minor inhibition of CYP3A4/5 metabolism of argatroban by clarithromycin.
What to do
Monitor aPTT per usual argatroban protocols and adjust the infusion accordingly.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Clarithromycin
- Astemizole + Clarithromycin Contraindicated
- Avanafil + Clarithromycin Contraindicated
- Cisapride + Clarithromycin Contraindicated
- Clarithromycin + Colchicine Contraindicated
- Clarithromycin + Conivaptan Contraindicated
- Clarithromycin + Dihydroergotamine Contraindicated
Other interactions of Argatroban
- Argatroban + Defibrotide Contraindicated
- Argatroban + Ketorolac Contraindicated
- Argatroban + Mifepristone Contraindicated
- Abciximab + Argatroban Major
- Acalabrutinib + Argatroban Major
- Acetylsalicylic acid + Argatroban Major
Frequently asked questions
Can I take Argatroban with Clarithromycin?
MediHelp rates the interaction as minor. Argatroban and Clarithromycin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Argatroban is cleared mostly by hepatic metabolism with a small CYP3A4 contribution. Clarithromycin has shown only a limited effect on argatroban exposure, so clinically important bleeding risk from this interaction appears small.
How serious is the interaction between Argatroban and Clarithromycin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor aPTT per usual argatroban protocols and adjust the infusion accordingly.
What other medicines interact with Clarithromycin?
MediHelp also lists interactions of Clarithromycin with, for example, Astemizole, Avanafil, Cisapride. The full list is on the Clarithromycin page.
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