Drug interactions
Argatroban + Dalteparin
Severity: Major
Argatroban and Dalteparin: major interaction.
Last updated Sources: UK SmPC
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Combining a direct thrombin inhibitor with a low molecular weight heparin gives additive anticoagulation and increases bleeding risk. Argatroban also affects coagulation assays, complicating monitoring.
What this interaction means in plain words
Argatroban and Dalteparin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Argatroban belongs to Cardiovascular; Dalteparin belongs to Cardiovascular.
Why it happens
Additive anticoagulation from direct thrombin inhibition plus antithrombin-mediated factor Xa inhibition.
What to do
Avoid concurrent use; in suspected HIT stop dalteparin before starting argatroban. Monitor aPTT and bleeding.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Dalteparin
- Dalteparin + Defibrotide Contraindicated
- Dalteparin + Ketorolac Contraindicated
- Dalteparin + Mifepristone Contraindicated
- Abciximab + Dalteparin Major
- Acalabrutinib + Dalteparin Major
- Aceclofenac + Dalteparin Major
Other interactions of Argatroban
- Argatroban + Defibrotide Contraindicated
- Argatroban + Ketorolac Contraindicated
- Argatroban + Mifepristone Contraindicated
- Abciximab + Argatroban Major
- Acalabrutinib + Argatroban Major
- Acetylsalicylic acid + Argatroban Major
Frequently asked questions
Can I take Argatroban with Dalteparin?
MediHelp rates the interaction as major. Argatroban and Dalteparin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Combining a direct thrombin inhibitor with a low molecular weight heparin gives additive anticoagulation and increases bleeding risk. Argatroban also affects coagulation assays, complicating monitoring.
How serious is the interaction between Argatroban and Dalteparin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use; in suspected HIT stop dalteparin before starting argatroban. Monitor aPTT and bleeding.
What other medicines interact with Dalteparin?
MediHelp also lists interactions of Dalteparin with, for example, Defibrotide, Ketorolac, Mifepristone. The full list is on the Dalteparin page.
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