Drug interactions
Argatroban + Gemcitabine
Severity: Moderate
Argatroban and Gemcitabine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Gemcitabine often causes thrombocytopenia, which raises bleeding risk in anticoagulated patients. Argatroban adds anticoagulant effect, so bleeding may be more likely.
What this interaction means in plain words
Argatroban and Gemcitabine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Argatroban belongs to Cardiovascular; Gemcitabine belongs to Oncology.
Why it happens
Additive bleeding risk from chemotherapy-induced thrombocytopenia plus direct thrombin inhibition.
What to do
Monitor platelet counts and aPTT, and watch for bleeding. Adjust or hold argatroban if platelets fall markedly.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Gemcitabine
Other interactions of Argatroban
- Argatroban + Defibrotide Contraindicated
- Argatroban + Ketorolac Contraindicated
- Argatroban + Mifepristone Contraindicated
- Abciximab + Argatroban Major
- Acalabrutinib + Argatroban Major
- Acetylsalicylic acid + Argatroban Major
Frequently asked questions
Can I take Argatroban with Gemcitabine?
MediHelp rates the interaction as moderate. Argatroban and Gemcitabine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Gemcitabine often causes thrombocytopenia, which raises bleeding risk in anticoagulated patients. Argatroban adds anticoagulant effect, so bleeding may be more likely.
How serious is the interaction between Argatroban and Gemcitabine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor platelet counts and aPTT, and watch for bleeding. Adjust or hold argatroban if platelets fall markedly.
What other medicines interact with Gemcitabine?
MediHelp also lists interactions of Gemcitabine with, for example, Adenovirus types 4 and 7 live, Axicabtagene ciloleucel, Belatacept. The full list is on the Gemcitabine page.
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