Drug interactions
Argatroban + Lornoxicam
Severity: Moderate
Argatroban and Lornoxicam: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lornoxicam is a potent NSAID that inhibits platelet aggregation and can cause gastrointestinal ulceration. With argatroban the risk of bleeding is increased.
What this interaction means in plain words
Argatroban and Lornoxicam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Argatroban belongs to Cardiovascular; Lornoxicam belongs to Musculoskeletal.
Why it happens
Additive hemostatic impairment from direct thrombin inhibition and NSAID-mediated platelet dysfunction and mucosal injury.
What to do
Avoid concurrent use where possible and choose paracetamol for analgesia; if combined, monitor for bleeding and hemoglobin and aPTT.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Argatroban
- Argatroban + Defibrotide Contraindicated
- Argatroban + Ketorolac Contraindicated
- Argatroban + Mifepristone Contraindicated
- Abciximab + Argatroban Major
- Acalabrutinib + Argatroban Major
- Acetylsalicylic acid + Argatroban Major
Other interactions of Lornoxicam
Frequently asked questions
Can I take Argatroban with Lornoxicam?
MediHelp rates the interaction as moderate. Argatroban and Lornoxicam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lornoxicam is a potent NSAID that inhibits platelet aggregation and can cause gastrointestinal ulceration. With argatroban the risk of bleeding is increased.
How serious is the interaction between Argatroban and Lornoxicam?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use where possible and choose paracetamol for analgesia; if combined, monitor for bleeding and hemoglobin and aPTT.
What other medicines interact with Argatroban?
MediHelp also lists interactions of Argatroban with, for example, Defibrotide, Ketorolac, Mifepristone. The full list is on the Argatroban page.
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