Drug interactions
Argatroban + Rivaroxaban
Severity: Major
Argatroban and Rivaroxaban: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs are anticoagulants, so overlapping use increases the risk of major bleeding. Argatroban also raises the INR, which complicates monitoring during transitions.
What this interaction means in plain words
Argatroban and Rivaroxaban can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Argatroban belongs to Cardiovascular; Rivaroxaban belongs to Cardiovascular.
Why it happens
Additive anticoagulation through direct thrombin inhibition (argatroban) and direct factor Xa inhibition (rivaroxaban).
What to do
Avoid simultaneous administration; when transitioning, start rivaroxaban at the time argatroban is stopped, or follow a local protocol, and monitor for bleeding.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Argatroban and Rivaroxaban, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
References
Other interactions of Rivaroxaban
- Defibrotide + Rivaroxaban Contraindicated
- Ketoconazole + Rivaroxaban Contraindicated
- Ketorolac + Rivaroxaban Contraindicated
- Abciximab + Rivaroxaban Major
- Acalabrutinib + Rivaroxaban Major
- Acetylsalicylic acid + Rivaroxaban Major
Other interactions of Argatroban
- Argatroban + Defibrotide Contraindicated
- Argatroban + Ketorolac Contraindicated
- Argatroban + Mifepristone Contraindicated
- Abciximab + Argatroban Major
- Acalabrutinib + Argatroban Major
- Acetylsalicylic acid + Argatroban Major
Frequently asked questions
Can I take Argatroban with Rivaroxaban?
MediHelp rates the interaction as major. Argatroban and Rivaroxaban can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both drugs are anticoagulants, so overlapping use increases the risk of major bleeding. Argatroban also raises the INR, which complicates monitoring during transitions.
How serious is the interaction between Argatroban and Rivaroxaban?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid simultaneous administration; when transitioning, start rivaroxaban at the time argatroban is stopped, or follow a local protocol, and monitor for bleeding.
What other medicines interact with Rivaroxaban?
MediHelp also lists interactions of Rivaroxaban with, for example, Defibrotide, Ketoconazole, Ketorolac. The full list is on the Rivaroxaban page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
