Drug interactions
Aripiprazole + Avapritinib
Severity: Moderate
Aripiprazole and Avapritinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Avapritinib can cause cognitive effects and somnolence, which may add to the sedation caused by aripiprazole. Avapritinib is also a moderate CYP3A4 inducer, which may lower aripiprazole exposure to some degree.
What this interaction means in plain words
Aripiprazole and Avapritinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Aripiprazole belongs to Central Nervous System; Avapritinib belongs to Oncology.
Why it happens
Additive CNS effects, and possible CYP3A4 induction by avapritinib reducing aripiprazole levels.
What to do
Monitor for sedation, confusion and memory changes, and watch for loss of antipsychotic efficacy; adjust the aripiprazole dose according to clinical response.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Aripiprazole
- Aripiprazole + Pimozide Contraindicated
- Aripiprazole + Thioridazine Contraindicated
- Amisulpride + Aripiprazole Major
- Aripiprazole + Arsenic trioxide Major
- Aripiprazole + Calcium / magnesium / potassium / sodium oxybates Major
- Aripiprazole + Carbamazepine Major
Other interactions of Avapritinib
Frequently asked questions
Can I take Aripiprazole with Avapritinib?
MediHelp rates the interaction as moderate. Aripiprazole and Avapritinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Avapritinib can cause cognitive effects and somnolence, which may add to the sedation caused by aripiprazole. Avapritinib is also a moderate CYP3A4 inducer, which may lower aripiprazole exposure to some degree.
How serious is the interaction between Aripiprazole and Avapritinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for sedation, confusion and memory changes, and watch for loss of antipsychotic efficacy; adjust the aripiprazole dose according to clinical response.
What other medicines interact with Aripiprazole?
MediHelp also lists interactions of Aripiprazole with, for example, Pimozide, Thioridazine, Amisulpride. The full list is on the Aripiprazole page.
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