Drug interactions
Aripiprazole + Bedaquiline
Severity: Moderate
Aripiprazole and Bedaquiline: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Bedaquiline carries a labeled QT prolongation warning. Aripiprazole has little QT effect on its own, but combining them may modestly add to the risk of arrhythmia.
What this interaction means in plain words
Aripiprazole and Bedaquiline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Aripiprazole belongs to Central Nervous System; Bedaquiline belongs to Anti Bacterial.
Why it happens
Additive prolongation of cardiac repolarization.
What to do
Perform baseline and periodic ECGs and monitor potassium, calcium and magnesium. Stop or reconsider if QTc becomes markedly prolonged.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Aripiprazole
- Aripiprazole + Pimozide Contraindicated
- Aripiprazole + Thioridazine Contraindicated
- Amisulpride + Aripiprazole Major
- Aripiprazole + Arsenic trioxide Major
- Aripiprazole + Calcium / magnesium / potassium / sodium oxybates Major
- Aripiprazole + Carbamazepine Major
Other interactions of Bedaquiline
- Bedaquiline + Ziprasidone Contraindicated
- Alfuzosin + Bedaquiline Major
- Amiodarone + Bedaquiline Major
- Amisulpride + Bedaquiline Major
- Amitriptyline + Bedaquiline Major
- Amobarbital + Bedaquiline Major
Frequently asked questions
Can I take Aripiprazole with Bedaquiline?
MediHelp rates the interaction as moderate. Aripiprazole and Bedaquiline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Bedaquiline carries a labeled QT prolongation warning. Aripiprazole has little QT effect on its own, but combining them may modestly add to the risk of arrhythmia.
How serious is the interaction between Aripiprazole and Bedaquiline?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Perform baseline and periodic ECGs and monitor potassium, calcium and magnesium. Stop or reconsider if QTc becomes markedly prolonged.
What other medicines interact with Aripiprazole?
MediHelp also lists interactions of Aripiprazole with, for example, Pimozide, Thioridazine, Amisulpride. The full list is on the Aripiprazole page.
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