Drug interactions
Aripiprazole + Bromocriptine
Severity: Moderate
Aripiprazole and Bromocriptine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Aripiprazole is a D2 partial agonist and may blunt the effect of bromocriptine in Parkinson disease or hyperprolactinemia. Bromocriptine could also worsen psychosis.
What this interaction means in plain words
Aripiprazole and Bromocriptine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Aripiprazole belongs to Central Nervous System; Bromocriptine belongs to Central Nervous System.
Why it happens
Pharmacodynamic opposition at dopamine D2 receptors.
What to do
Monitor symptom control, prolactin if relevant, and psychiatric status. Adjust doses or choose alternatives if either therapy is losing effect.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Aripiprazole
- Aripiprazole + Pimozide Contraindicated
- Aripiprazole + Thioridazine Contraindicated
- Amisulpride + Aripiprazole Major
- Aripiprazole + Arsenic trioxide Major
- Aripiprazole + Calcium / magnesium / potassium / sodium oxybates Major
- Aripiprazole + Carbamazepine Major
Other interactions of Bromocriptine
Frequently asked questions
Can I take Aripiprazole with Bromocriptine?
MediHelp rates the interaction as moderate. Aripiprazole and Bromocriptine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Aripiprazole is a D2 partial agonist and may blunt the effect of bromocriptine in Parkinson disease or hyperprolactinemia. Bromocriptine could also worsen psychosis.
How serious is the interaction between Aripiprazole and Bromocriptine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor symptom control, prolactin if relevant, and psychiatric status. Adjust doses or choose alternatives if either therapy is losing effect.
What other medicines interact with Aripiprazole?
MediHelp also lists interactions of Aripiprazole with, for example, Pimozide, Thioridazine, Amisulpride. The full list is on the Aripiprazole page.
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