Drug interactions
Aripiprazole + Bupropion
Severity: Moderate
Aripiprazole and Bupropion: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Bupropion is a strong CYP2D6 inhibitor and can raise aripiprazole exposure, increasing akathisia, sedation, and other adverse effects.
What this interaction means in plain words
Aripiprazole and Bupropion can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Aripiprazole belongs to Central Nervous System; Bupropion belongs to Central Nervous System.
Why it happens
Inhibition of CYP2D6-mediated aripiprazole metabolism by bupropion.
What to do
Consider reducing the aripiprazole dose, since labeling advises halving it with strong CYP2D6 inhibitors. Monitor for akathisia, sedation and extrapyramidal symptoms.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Bupropion
- Bupropion + Isocarboxazid Contraindicated
- Bupropion + Linezolid Contraindicated
- Bupropion + Phenelzine Contraindicated
- Bupropion + Rasagiline Contraindicated
- Bupropion + Selegiline Contraindicated
- Bupropion + Selegiline transdermal Contraindicated
Other interactions of Aripiprazole
- Aripiprazole + Pimozide Contraindicated
- Aripiprazole + Thioridazine Contraindicated
- Amisulpride + Aripiprazole Major
- Aripiprazole + Arsenic trioxide Major
- Aripiprazole + Calcium / magnesium / potassium / sodium oxybates Major
- Aripiprazole + Carbamazepine Major
Frequently asked questions
Can I take Aripiprazole with Bupropion?
MediHelp rates the interaction as moderate. Aripiprazole and Bupropion can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Bupropion is a strong CYP2D6 inhibitor and can raise aripiprazole exposure, increasing akathisia, sedation, and other adverse effects.
How serious is the interaction between Aripiprazole and Bupropion?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider reducing the aripiprazole dose, since labeling advises halving it with strong CYP2D6 inhibitors. Monitor for akathisia, sedation and extrapyramidal symptoms.
What other medicines interact with Bupropion?
MediHelp also lists interactions of Bupropion with, for example, Isocarboxazid, Linezolid, Phenelzine. The full list is on the Bupropion page.
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