Drug interactions
Aripiprazole + Clobazam
Severity: Moderate
Aripiprazole and Clobazam: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Clobazam is a benzodiazepine that adds to the sedative and respiratory depressant effects of aripiprazole. Its metabolite is a weak CYP2D6 inhibitor, which could modestly raise aripiprazole exposure.
What this interaction means in plain words
Aripiprazole and Clobazam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Aripiprazole belongs to Central Nervous System; Clobazam belongs to Central Nervous System.
Why it happens
Additive CNS depression, with weak CYP2D6 inhibition by clobazam or its metabolite.
What to do
Monitor sedation, cognition and respiratory status, especially during titration. Consider a lower aripiprazole dose if adverse effects emerge.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Aripiprazole
- Aripiprazole + Pimozide Contraindicated
- Aripiprazole + Thioridazine Contraindicated
- Amisulpride + Aripiprazole Major
- Aripiprazole + Arsenic trioxide Major
- Aripiprazole + Calcium / magnesium / potassium / sodium oxybates Major
- Aripiprazole + Carbamazepine Major
Other interactions of Clobazam
- Amobarbital + Clobazam Major
- Buprenorphine + Clobazam Major
- Butorphanol + Clobazam Major
- Carisoprodol + Clobazam Major
- Chloral hydrate + Clobazam Major
- Clobazam + Clozapine Major
Frequently asked questions
Can I take Aripiprazole with Clobazam?
MediHelp rates the interaction as moderate. Aripiprazole and Clobazam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Clobazam is a benzodiazepine that adds to the sedative and respiratory depressant effects of aripiprazole. Its metabolite is a weak CYP2D6 inhibitor, which could modestly raise aripiprazole exposure.
How serious is the interaction between Aripiprazole and Clobazam?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor sedation, cognition and respiratory status, especially during titration. Consider a lower aripiprazole dose if adverse effects emerge.
What other medicines interact with Aripiprazole?
MediHelp also lists interactions of Aripiprazole with, for example, Pimozide, Thioridazine, Amisulpride. The full list is on the Aripiprazole page.
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