Drug interactions
Aripiprazole + Clomipramine
Severity: Moderate
Aripiprazole and Clomipramine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Clomipramine may raise aripiprazole levels through CYP2D6 inhibition, and both drugs can cause sedation. QT effects are modest with aripiprazole but may add to the tricyclic effect.
What this interaction means in plain words
Aripiprazole and Clomipramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Aripiprazole belongs to Central Nervous System; Clomipramine belongs to Central Nervous System.
Why it happens
Additive CNS depression and minor QT effects, with CYP2D6 inhibition by clomipramine raising aripiprazole exposure.
What to do
Monitor for sedation, akathisia and orthostasis, and consider a lower aripiprazole dose. Check an ECG if other risk factors exist.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Clomipramine
- Arsenic trioxide + Clomipramine Contraindicated
- Clomipramine + Dofetilide Contraindicated
- Clomipramine + Droperidol Contraindicated
- Clomipramine + Isocarboxazid Contraindicated
- Clomipramine + Methylene blue Contraindicated
- Clomipramine + Pentamidine Contraindicated
Other interactions of Aripiprazole
- Aripiprazole + Pimozide Contraindicated
- Aripiprazole + Thioridazine Contraindicated
- Amisulpride + Aripiprazole Major
- Aripiprazole + Arsenic trioxide Major
- Aripiprazole + Calcium / magnesium / potassium / sodium oxybates Major
- Aripiprazole + Carbamazepine Major
Frequently asked questions
Can I take Aripiprazole with Clomipramine?
MediHelp rates the interaction as moderate. Aripiprazole and Clomipramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Clomipramine may raise aripiprazole levels through CYP2D6 inhibition, and both drugs can cause sedation. QT effects are modest with aripiprazole but may add to the tricyclic effect.
How serious is the interaction between Aripiprazole and Clomipramine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for sedation, akathisia and orthostasis, and consider a lower aripiprazole dose. Check an ECG if other risk factors exist.
What other medicines interact with Clomipramine?
MediHelp also lists interactions of Clomipramine with, for example, Arsenic trioxide, Dofetilide, Droperidol. The full list is on the Clomipramine page.
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