Drug interactions
Aripiprazole + Crizotinib
Severity: Moderate
Aripiprazole and Crizotinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Crizotinib can prolong the QT interval and cause bradycardia, and aripiprazole has a small QT effect. Crizotinib also inhibits CYP3A4, which may raise aripiprazole levels.
What this interaction means in plain words
Aripiprazole and Crizotinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Aripiprazole belongs to Central Nervous System; Crizotinib belongs to Oncology.
Why it happens
Additive QT prolongation plus CYP3A4 inhibition by crizotinib increasing aripiprazole exposure.
What to do
Monitor ECG and electrolytes, and watch for aripiprazole adverse effects such as akathisia or sedation. Consider reducing the aripiprazole dose if effects emerge.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Aripiprazole
- Aripiprazole + Pimozide Contraindicated
- Aripiprazole + Thioridazine Contraindicated
- Amisulpride + Aripiprazole Major
- Aripiprazole + Arsenic trioxide Major
- Aripiprazole + Calcium / magnesium / potassium / sodium oxybates Major
- Aripiprazole + Carbamazepine Major
Other interactions of Crizotinib
- Crizotinib + Flibanserin Contraindicated
- Crizotinib + Lomitapide Contraindicated
- Crizotinib + Lonafarnib Contraindicated
- Crizotinib + Pimozide Contraindicated
- Crizotinib + Saquinavir Contraindicated
- Crizotinib + Thioridazine Contraindicated
Frequently asked questions
Can I take Aripiprazole with Crizotinib?
MediHelp rates the interaction as moderate. Aripiprazole and Crizotinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Crizotinib can prolong the QT interval and cause bradycardia, and aripiprazole has a small QT effect. Crizotinib also inhibits CYP3A4, which may raise aripiprazole levels.
How serious is the interaction between Aripiprazole and Crizotinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor ECG and electrolytes, and watch for aripiprazole adverse effects such as akathisia or sedation. Consider reducing the aripiprazole dose if effects emerge.
What other medicines interact with Aripiprazole?
MediHelp also lists interactions of Aripiprazole with, for example, Pimozide, Thioridazine, Amisulpride. The full list is on the Aripiprazole page.
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