Drug interactions
Aripiprazole + Dacomitinib
Severity: Moderate
Aripiprazole and Dacomitinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dacomitinib strongly inhibits CYP2D6, which is a main pathway for aripiprazole metabolism. Exposure to aripiprazole can rise, increasing dose-related adverse effects.
What this interaction means in plain words
Aripiprazole and Dacomitinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Aripiprazole belongs to Central Nervous System; Dacomitinib belongs to Oncology.
Why it happens
Dacomitinib inhibits CYP2D6, reducing aripiprazole clearance.
What to do
Reduce the aripiprazole dose to about half, as with strong CYP2D6 inhibitors, and monitor for akathisia, sedation and orthostasis.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Aripiprazole
- Aripiprazole + Pimozide Contraindicated
- Aripiprazole + Thioridazine Contraindicated
- Amisulpride + Aripiprazole Major
- Aripiprazole + Arsenic trioxide Major
- Aripiprazole + Calcium / magnesium / potassium / sodium oxybates Major
- Aripiprazole + Carbamazepine Major
Other interactions of Dacomitinib
- Dacomitinib + Thioridazine Contraindicated
- Amitriptyline + Dacomitinib Major
- Atomoxetine + Dacomitinib Major
- Brexpiprazole + Dacomitinib Major
- Clomipramine + Dacomitinib Major
- Dacomitinib + Desipramine Major
Frequently asked questions
Can I take Aripiprazole with Dacomitinib?
MediHelp rates the interaction as moderate. Aripiprazole and Dacomitinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dacomitinib strongly inhibits CYP2D6, which is a main pathway for aripiprazole metabolism. Exposure to aripiprazole can rise, increasing dose-related adverse effects.
How serious is the interaction between Aripiprazole and Dacomitinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Reduce the aripiprazole dose to about half, as with strong CYP2D6 inhibitors, and monitor for akathisia, sedation and orthostasis.
What other medicines interact with Aripiprazole?
MediHelp also lists interactions of Aripiprazole with, for example, Pimozide, Thioridazine, Amisulpride. The full list is on the Aripiprazole page.
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