Drug interactions
Aripiprazole + Darunavir
Severity: Moderate
Aripiprazole and Darunavir: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Darunavir is usually given with ritonavir or cobicistat, which strongly inhibit CYP3A4 and can raise aripiprazole concentrations. This may increase dose-related effects such as akathisia, sedation, and orthostatic hypotension.
What this interaction means in plain words
Aripiprazole and Darunavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Aripiprazole belongs to Central Nervous System; Darunavir belongs to Anti Virals.
Why it happens
Boosted darunavir regimens inhibit CYP3A4, the enzyme that metabolizes aripiprazole.
What to do
Aripiprazole labeling advises reducing the dose to about half with strong CYP3A4 inhibitors; monitor for adverse effects and restore the dose after the inhibitor is stopped.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Aripiprazole
- Aripiprazole + Pimozide Contraindicated
- Aripiprazole + Thioridazine Contraindicated
- Amisulpride + Aripiprazole Major
- Aripiprazole + Arsenic trioxide Major
- Aripiprazole + Calcium / magnesium / potassium / sodium oxybates Major
- Aripiprazole + Carbamazepine Major
Other interactions of Darunavir
- Alfuzosin + Darunavir Contraindicated
- Avanafil + Darunavir Contraindicated
- Darunavir + Dronedarone Contraindicated
- Darunavir + Eletriptan Contraindicated
- Darunavir + Ergotamine Contraindicated
- Darunavir + Flibanserin Contraindicated
Frequently asked questions
Can I take Aripiprazole with Darunavir?
MediHelp rates the interaction as moderate. Aripiprazole and Darunavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Darunavir is usually given with ritonavir or cobicistat, which strongly inhibit CYP3A4 and can raise aripiprazole concentrations. This may increase dose-related effects such as akathisia, sedation, and orthostatic hypotension.
How serious is the interaction between Aripiprazole and Darunavir?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Aripiprazole labeling advises reducing the dose to about half with strong CYP3A4 inhibitors; monitor for adverse effects and restore the dose after the inhibitor is stopped.
What other medicines interact with Aripiprazole?
MediHelp also lists interactions of Aripiprazole with, for example, Pimozide, Thioridazine, Amisulpride. The full list is on the Aripiprazole page.
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