Drug interactions
Aripiprazole + Dasatinib
Severity: Moderate
Aripiprazole and Dasatinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dasatinib is a weak CYP3A4 inhibitor and may modestly raise aripiprazole exposure. Both drugs can also prolong the QT interval, although aripiprazole has low QT liability.
What this interaction means in plain words
Aripiprazole and Dasatinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Aripiprazole belongs to Central Nervous System; Dasatinib belongs to Oncology.
Why it happens
Weak CYP3A4 inhibition by dasatinib plus additive QT prolongation.
What to do
Monitor for aripiprazole adverse effects and obtain an ECG with electrolyte checks, especially with other QT-prolonging drugs or cardiac risk factors.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Aripiprazole
- Aripiprazole + Pimozide Contraindicated
- Aripiprazole + Thioridazine Contraindicated
- Amisulpride + Aripiprazole Major
- Aripiprazole + Arsenic trioxide Major
- Aripiprazole + Calcium / magnesium / potassium / sodium oxybates Major
- Aripiprazole + Carbamazepine Major
Other interactions of Dasatinib
- Dasatinib + Saquinavir Contraindicated
- Dasatinib + Thioridazine Contraindicated
- Adagrasib + Dasatinib Major
- Amiodarone + Dasatinib Major
- Amisulpride + Dasatinib Major
- Amitriptyline + Dasatinib Major
Frequently asked questions
Can I take Aripiprazole with Dasatinib?
MediHelp rates the interaction as moderate. Aripiprazole and Dasatinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dasatinib is a weak CYP3A4 inhibitor and may modestly raise aripiprazole exposure. Both drugs can also prolong the QT interval, although aripiprazole has low QT liability.
How serious is the interaction between Aripiprazole and Dasatinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for aripiprazole adverse effects and obtain an ECG with electrolyte checks, especially with other QT-prolonging drugs or cardiac risk factors.
What other medicines interact with Aripiprazole?
MediHelp also lists interactions of Aripiprazole with, for example, Pimozide, Thioridazine, Amisulpride. The full list is on the Aripiprazole page.
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