Drug interactions
Aripiprazole + Desflurane
Severity: Moderate
Aripiprazole and Desflurane: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both agents have been associated with QTc prolongation, and volatile anesthetics can also provoke arrhythmias during surgery. Aripiprazole's own effect on the QT interval is small, so the added risk is modest but present in patients with other risk factors.
What this interaction means in plain words
Aripiprazole and Desflurane can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Aripiprazole belongs to Central Nervous System; Desflurane belongs to Central Nervous System.
Why it happens
Additive pharmacodynamic effect on ventricular repolarization (QTc prolongation).
What to do
Check baseline ECG and correct potassium and magnesium before anesthesia in patients with other QT risk factors. Monitor ECG intraoperatively and continue aripiprazole unless QT risk is high.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Aripiprazole
- Aripiprazole + Pimozide Contraindicated
- Aripiprazole + Thioridazine Contraindicated
- Amisulpride + Aripiprazole Major
- Aripiprazole + Arsenic trioxide Major
- Aripiprazole + Calcium / magnesium / potassium / sodium oxybates Major
- Aripiprazole + Carbamazepine Major
Other interactions of Desflurane
Frequently asked questions
Can I take Aripiprazole with Desflurane?
MediHelp rates the interaction as moderate. Aripiprazole and Desflurane can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both agents have been associated with QTc prolongation, and volatile anesthetics can also provoke arrhythmias during surgery. Aripiprazole's own effect on the QT interval is small, so the added risk is modest but present in patients with other risk factors.
How serious is the interaction between Aripiprazole and Desflurane?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check baseline ECG and correct potassium and magnesium before anesthesia in patients with other QT risk factors. Monitor ECG intraoperatively and continue aripiprazole unless QT risk is high.
What other medicines interact with Aripiprazole?
MediHelp also lists interactions of Aripiprazole with, for example, Pimozide, Thioridazine, Amisulpride. The full list is on the Aripiprazole page.
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