Drug interactions
Aripiprazole + Dicyclomine
Severity: Minor
Aripiprazole and Dicyclomine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Aripiprazole has weak anticholinergic activity, so adding dicyclomine may increase constipation, urinary retention and confusion. Dicyclomine slows gut motility, which could slightly alter aripiprazole absorption, though this is unlikely to be significant.
What this interaction means in plain words
Aripiprazole and Dicyclomine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Aripiprazole belongs to Central Nervous System; Dicyclomine belongs to Respiratory.
Why it happens
Additive anticholinergic effects; delayed gastric emptying may modestly affect absorption.
What to do
Monitor for anticholinergic effects such as constipation and urinary retention, especially in older patients.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Dicyclomine
- Clozapine + Dicyclomine Major
- Dicyclomine + Henbane Major
- Dicyclomine + Imipramine Major
- Dicyclomine + Pramlintide Major
- Abobotulinumtoxina + Dicyclomine Moderate
- Aclidinium + Dicyclomine Moderate
Other interactions of Aripiprazole
- Aripiprazole + Pimozide Contraindicated
- Aripiprazole + Thioridazine Contraindicated
- Amisulpride + Aripiprazole Major
- Aripiprazole + Arsenic trioxide Major
- Aripiprazole + Calcium / magnesium / potassium / sodium oxybates Major
- Aripiprazole + Carbamazepine Major
Frequently asked questions
Can I take Aripiprazole with Dicyclomine?
MediHelp rates the interaction as minor. Aripiprazole and Dicyclomine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Aripiprazole has weak anticholinergic activity, so adding dicyclomine may increase constipation, urinary retention and confusion. Dicyclomine slows gut motility, which could slightly alter aripiprazole absorption, though this is unlikely to be significant.
How serious is the interaction between Aripiprazole and Dicyclomine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for anticholinergic effects such as constipation and urinary retention, especially in older patients.
What other medicines interact with Dicyclomine?
MediHelp also lists interactions of Dicyclomine with, for example, Clozapine, Henbane, Imipramine. The full list is on the Dicyclomine page.
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