Drug interactions
Aripiprazole + Eliglustat
Severity: Moderate
Aripiprazole and Eliglustat: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Eliglustat can raise the QT interval at high exposures, and it is a CYP2D6 substrate and inhibitor. Aripiprazole is metabolized by CYP2D6 and CYP3A4, so levels may rise, and QT effects may be additive.
What this interaction means in plain words
Aripiprazole and Eliglustat can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Aripiprazole belongs to Central Nervous System; Eliglustat belongs to Miscellaneous.
Why it happens
Eliglustat inhibits CYP2D6, raising aripiprazole levels, with additive QT effects.
What to do
Consider reducing the aripiprazole dose and monitor ECG and adverse effects such as akathisia.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Aripiprazole
- Aripiprazole + Pimozide Contraindicated
- Aripiprazole + Thioridazine Contraindicated
- Amisulpride + Aripiprazole Major
- Aripiprazole + Arsenic trioxide Major
- Aripiprazole + Calcium / magnesium / potassium / sodium oxybates Major
- Aripiprazole + Carbamazepine Major
Other interactions of Eliglustat
- Amiodarone + Eliglustat Contraindicated
- Clarithromycin + Eliglustat Contraindicated
- Dronedarone + Eliglustat Contraindicated
- Eliglustat + Itraconazole Contraindicated
- Eliglustat + Ketoconazole Contraindicated
- Eliglustat + Pimozide Contraindicated
Frequently asked questions
Can I take Aripiprazole with Eliglustat?
MediHelp rates the interaction as moderate. Aripiprazole and Eliglustat can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Eliglustat can raise the QT interval at high exposures, and it is a CYP2D6 substrate and inhibitor. Aripiprazole is metabolized by CYP2D6 and CYP3A4, so levels may rise, and QT effects may be additive.
How serious is the interaction between Aripiprazole and Eliglustat?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider reducing the aripiprazole dose and monitor ECG and adverse effects such as akathisia.
What other medicines interact with Aripiprazole?
MediHelp also lists interactions of Aripiprazole with, for example, Pimozide, Thioridazine, Amisulpride. The full list is on the Aripiprazole page.
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