Drug interactions
Aripiprazole + Ephedrine
Severity: Minor
Aripiprazole and Ephedrine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ephedrine is a sympathomimetic and aripiprazole has alpha-1 blocking activity, so the pressor response to ephedrine may be partly reduced. Ephedrine may also counter sedation and cause agitation or tachycardia.
What this interaction means in plain words
Aripiprazole and Ephedrine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Aripiprazole belongs to Central Nervous System; Ephedrine belongs to Cardiovascular.
Why it happens
Opposing pharmacodynamic effects: sympathomimetic stimulation versus alpha-1 adrenergic antagonism.
What to do
Monitor blood pressure and heart rate when ephedrine is given to treat hypotension, and titrate the dose to effect.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Aripiprazole
- Aripiprazole + Pimozide Contraindicated
- Aripiprazole + Thioridazine Contraindicated
- Amisulpride + Aripiprazole Major
- Aripiprazole + Arsenic trioxide Major
- Aripiprazole + Calcium / magnesium / potassium / sodium oxybates Major
- Aripiprazole + Carbamazepine Major
Other interactions of Ephedrine
- Ephedrine + Isocarboxazid Contraindicated
- Ephedrine + Phenelzine Contraindicated
- Ephedrine + Procarbazine Contraindicated
- Ephedrine + Rasagiline Contraindicated
- Ephedrine + Selegiline Contraindicated
- Ephedrine + Tranylcypromine Contraindicated
Frequently asked questions
Can I take Aripiprazole with Ephedrine?
MediHelp rates the interaction as minor. Aripiprazole and Ephedrine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Ephedrine is a sympathomimetic and aripiprazole has alpha-1 blocking activity, so the pressor response to ephedrine may be partly reduced. Ephedrine may also counter sedation and cause agitation or tachycardia.
How serious is the interaction between Aripiprazole and Ephedrine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and heart rate when ephedrine is given to treat hypotension, and titrate the dose to effect.
What other medicines interact with Aripiprazole?
MediHelp also lists interactions of Aripiprazole with, for example, Pimozide, Thioridazine, Amisulpride. The full list is on the Aripiprazole page.
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