Drug interactions
Aripiprazole + Eslicarbazepine
Severity: Moderate
Aripiprazole and Eslicarbazepine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Eslicarbazepine is a weak to moderate CYP3A4 inducer and may lower aripiprazole exposure. This can reduce antipsychotic efficacy and risk relapse or loss of symptom control.
What this interaction means in plain words
Aripiprazole and Eslicarbazepine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Aripiprazole belongs to Central Nervous System; Eslicarbazepine belongs to Central Nervous System.
Why it happens
Induction of CYP3A4 by eslicarbazepine increases aripiprazole metabolism.
What to do
Monitor for loss of psychiatric response when eslicarbazepine is started and raise the aripiprazole dose if needed. Reduce the dose again if eslicarbazepine is discontinued.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Aripiprazole
- Aripiprazole + Pimozide Contraindicated
- Aripiprazole + Thioridazine Contraindicated
- Amisulpride + Aripiprazole Major
- Aripiprazole + Arsenic trioxide Major
- Aripiprazole + Calcium / magnesium / potassium / sodium oxybates Major
- Aripiprazole + Carbamazepine Major
Other interactions of Eslicarbazepine
- Eslicarbazepine + Mavacamten Contraindicated
- Eslicarbazepine + Rilpivirine Contraindicated
- Artemether / lumefantrine + Eslicarbazepine Major
- Avapritinib + Eslicarbazepine Major
- Bedaquiline + Eslicarbazepine Major
- Benzhydrocodone / acetaminophen + Eslicarbazepine Major
Frequently asked questions
Can I take Aripiprazole with Eslicarbazepine?
MediHelp rates the interaction as moderate. Aripiprazole and Eslicarbazepine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Eslicarbazepine is a weak to moderate CYP3A4 inducer and may lower aripiprazole exposure. This can reduce antipsychotic efficacy and risk relapse or loss of symptom control.
How serious is the interaction between Aripiprazole and Eslicarbazepine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for loss of psychiatric response when eslicarbazepine is started and raise the aripiprazole dose if needed. Reduce the dose again if eslicarbazepine is discontinued.
What other medicines interact with Aripiprazole?
MediHelp also lists interactions of Aripiprazole with, for example, Pimozide, Thioridazine, Amisulpride. The full list is on the Aripiprazole page.
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