Drug interactions
Aripiprazole + Flibanserin
Severity: Moderate
Aripiprazole and Flibanserin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Flibanserin acts on serotonin receptors and aripiprazole is a partial agonist at dopamine and serotonin receptors. Additive CNS depression, sedation and hypotension may occur, and serotonergic or neuroleptic malignant syndrome features are theoretically possible. Aripiprazole is metabolized by CYP3A4 and CYP2D6, and flibanserin is a weak CYP3A4 inhibitor.
What this interaction means in plain words
Aripiprazole and Flibanserin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Aripiprazole belongs to Central Nervous System; Flibanserin belongs to Genitourinary.
Why it happens
Additive CNS depressant and serotonergic or dopaminergic receptor effects; the exact mechanism is not firmly established.
What to do
Monitor for sedation, hypotension, altered mental status, hyperthermia and rigidity. Counsel the patient about driving and alcohol avoidance.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Flibanserin
- Atazanavir + Flibanserin Contraindicated
- Ceritinib + Flibanserin Contraindicated
- Clarithromycin + Flibanserin Contraindicated
- Cobicistat + Flibanserin Contraindicated
- Conivaptan + Flibanserin Contraindicated
- Crizotinib + Flibanserin Contraindicated
Other interactions of Aripiprazole
- Aripiprazole + Pimozide Contraindicated
- Aripiprazole + Thioridazine Contraindicated
- Amisulpride + Aripiprazole Major
- Aripiprazole + Arsenic trioxide Major
- Aripiprazole + Calcium / magnesium / potassium / sodium oxybates Major
- Aripiprazole + Carbamazepine Major
Frequently asked questions
Can I take Aripiprazole with Flibanserin?
MediHelp rates the interaction as moderate. Aripiprazole and Flibanserin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Flibanserin acts on serotonin receptors and aripiprazole is a partial agonist at dopamine and serotonin receptors. Additive CNS depression, sedation and hypotension may occur, and serotonergic or neuroleptic malignant syndrome features are theoretically possible. Aripiprazole is metabolized by CYP3A4 and CYP2D6, and flibanserin is a weak CYP3A4 inhibitor.
How serious is the interaction between Aripiprazole and Flibanserin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for sedation, hypotension, altered mental status, hyperthermia and rigidity. Counsel the patient about driving and alcohol avoidance.
What other medicines interact with Flibanserin?
MediHelp also lists interactions of Flibanserin with, for example, Atazanavir, Ceritinib, Clarithromycin. The full list is on the Flibanserin page.
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