Drug interactions
Aripiprazole + Fosaprepitant
Severity: Minor
Aripiprazole and Fosaprepitant: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fosaprepitant is converted to aprepitant, a moderate and dose-dependent CYP3A4 inhibitor. With a single dose, the rise in aripiprazole exposure is probably small and transient.
What this interaction means in plain words
Aripiprazole and Fosaprepitant have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Aripiprazole belongs to Central Nervous System; Fosaprepitant belongs to Gastrointestinal Tract.
Why it happens
Temporary aprepitant inhibition of CYP3A4 metabolism of aripiprazole.
What to do
No routine dose change is needed for a single dose of fosaprepitant. Watch for sedation or akathisia if repeated dosing occurs.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Aripiprazole
- Aripiprazole + Pimozide Contraindicated
- Aripiprazole + Thioridazine Contraindicated
- Amisulpride + Aripiprazole Major
- Aripiprazole + Arsenic trioxide Major
- Aripiprazole + Calcium / magnesium / potassium / sodium oxybates Major
- Aripiprazole + Carbamazepine Major
Other interactions of Fosaprepitant
- Flibanserin + Fosaprepitant Contraindicated
- Fosaprepitant + Pimozide Contraindicated
- Alprazolam + Fosaprepitant Moderate
- Amiodarone + Fosaprepitant Moderate
- Amobarbital + Fosaprepitant Moderate
- Apalutamide + Fosaprepitant Moderate
Frequently asked questions
Can I take Aripiprazole with Fosaprepitant?
MediHelp rates the interaction as minor. Aripiprazole and Fosaprepitant have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Fosaprepitant is converted to aprepitant, a moderate and dose-dependent CYP3A4 inhibitor. With a single dose, the rise in aripiprazole exposure is probably small and transient.
How serious is the interaction between Aripiprazole and Fosaprepitant?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine dose change is needed for a single dose of fosaprepitant. Watch for sedation or akathisia if repeated dosing occurs.
What other medicines interact with Aripiprazole?
MediHelp also lists interactions of Aripiprazole with, for example, Pimozide, Thioridazine, Amisulpride. The full list is on the Aripiprazole page.
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