Drug interactions
Aripiprazole + Gilteritinib
Severity: Moderate
Aripiprazole and Gilteritinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Gilteritinib prolongs the QT interval, and aripiprazole may add a small effect. Combined use can raise the risk of torsades de pointes in susceptible patients.
What this interaction means in plain words
Aripiprazole and Gilteritinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Aripiprazole belongs to Central Nervous System; Gilteritinib belongs to Oncology.
Why it happens
Additive prolongation of cardiac repolarization.
What to do
Perform ECG at baseline and during therapy and keep potassium and magnesium within normal range. Reduce or interrupt a drug if QTc rises markedly.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Aripiprazole
- Aripiprazole + Pimozide Contraindicated
- Aripiprazole + Thioridazine Contraindicated
- Amisulpride + Aripiprazole Major
- Aripiprazole + Arsenic trioxide Major
- Aripiprazole + Calcium / magnesium / potassium / sodium oxybates Major
- Aripiprazole + Carbamazepine Major
Other interactions of Gilteritinib
- Gilteritinib + Pimozide Contraindicated
- Amiodarone + Gilteritinib Major
- Amisulpride + Gilteritinib Major
- Amitriptyline + Gilteritinib Major
- Anagrelide + Gilteritinib Major
- Apalutamide + Gilteritinib Major
Frequently asked questions
Can I take Aripiprazole with Gilteritinib?
MediHelp rates the interaction as moderate. Aripiprazole and Gilteritinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Gilteritinib prolongs the QT interval, and aripiprazole may add a small effect. Combined use can raise the risk of torsades de pointes in susceptible patients.
How serious is the interaction between Aripiprazole and Gilteritinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Perform ECG at baseline and during therapy and keep potassium and magnesium within normal range. Reduce or interrupt a drug if QTc rises markedly.
What other medicines interact with Aripiprazole?
MediHelp also lists interactions of Aripiprazole with, for example, Pimozide, Thioridazine, Amisulpride. The full list is on the Aripiprazole page.
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