Drug interactions
Aripiprazole + Granisetron
Severity: Moderate
Aripiprazole and Granisetron: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can prolong the QT interval slightly, so combined use may modestly add to arrhythmia risk. Aripiprazole has a relatively low QT liability, so the clinical risk is greatest in patients with other risk factors.
What this interaction means in plain words
Aripiprazole and Granisetron can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Aripiprazole belongs to Central Nervous System; Granisetron belongs to Gastrointestinal Tract.
Why it happens
Additive, mild QTc prolongation via effects on cardiac repolarization.
What to do
Use an ECG and electrolyte check in patients with cardiac risk factors or other QT-prolonging drugs; otherwise routine use is acceptable.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Granisetron
- Apomorphine + Granisetron Contraindicated
- Amiodarone + Granisetron Major
- Amisulpride + Granisetron Major
- Arsenic trioxide + Granisetron Major
- Artemether / lumefantrine + Granisetron Major
- Artemether + Granisetron Major
Other interactions of Aripiprazole
- Aripiprazole + Pimozide Contraindicated
- Aripiprazole + Thioridazine Contraindicated
- Amisulpride + Aripiprazole Major
- Aripiprazole + Arsenic trioxide Major
- Aripiprazole + Calcium / magnesium / potassium / sodium oxybates Major
- Aripiprazole + Carbamazepine Major
Frequently asked questions
Can I take Aripiprazole with Granisetron?
MediHelp rates the interaction as moderate. Aripiprazole and Granisetron can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs can prolong the QT interval slightly, so combined use may modestly add to arrhythmia risk. Aripiprazole has a relatively low QT liability, so the clinical risk is greatest in patients with other risk factors.
How serious is the interaction between Aripiprazole and Granisetron?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use an ECG and electrolyte check in patients with cardiac risk factors or other QT-prolonging drugs; otherwise routine use is acceptable.
What other medicines interact with Granisetron?
MediHelp also lists interactions of Granisetron with, for example, Apomorphine, Amiodarone, Amisulpride. The full list is on the Granisetron page.
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