Drug interactions
Aripiprazole + Haloperidol
Severity: Moderate
Aripiprazole and Haloperidol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Using two antipsychotics together adds to dopamine receptor blockade and raises the risk of extrapyramidal symptoms, akathisia and rarely neuroleptic malignant syndrome. Sedation and QT prolongation may also be additive, although aripiprazole has little QT effect.
What this interaction means in plain words
Aripiprazole and Haloperidol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Aripiprazole belongs to Central Nervous System; Haloperidol belongs to Central Nervous System.
Why it happens
Additive D2 receptor antagonism or partial agonism, with sedative and QT effects mainly from haloperidol.
What to do
Use the lowest effective doses and review the need for combination therapy. Monitor for movement disorders, sedation, rigidity or fever, and check ECG when QT risk factors are present.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Haloperidol
- Dofetilide + Haloperidol Contraindicated
- Dronedarone + Haloperidol Contraindicated
- Haloperidol + Ibutilide Contraindicated
- Haloperidol + Levoketoconazole Contraindicated
- Haloperidol + Panobinostat Contraindicated
- Haloperidol + Pimozide Contraindicated
Other interactions of Aripiprazole
- Aripiprazole + Pimozide Contraindicated
- Aripiprazole + Thioridazine Contraindicated
- Amisulpride + Aripiprazole Major
- Aripiprazole + Arsenic trioxide Major
- Aripiprazole + Calcium / magnesium / potassium / sodium oxybates Major
- Aripiprazole + Carbamazepine Major
Frequently asked questions
Can I take Aripiprazole with Haloperidol?
MediHelp rates the interaction as moderate. Aripiprazole and Haloperidol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Using two antipsychotics together adds to dopamine receptor blockade and raises the risk of extrapyramidal symptoms, akathisia and rarely neuroleptic malignant syndrome. Sedation and QT prolongation may also be additive, although aripiprazole has little QT effect.
How serious is the interaction between Aripiprazole and Haloperidol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective doses and review the need for combination therapy. Monitor for movement disorders, sedation, rigidity or fever, and check ECG when QT risk factors are present.
What other medicines interact with Haloperidol?
MediHelp also lists interactions of Haloperidol with, for example, Dofetilide, Dronedarone, Ibutilide. The full list is on the Haloperidol page.
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