Drug interactions
Aripiprazole + Hydroxyzine
Severity: Moderate
Aripiprazole and Hydroxyzine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Hydroxyzine is sedating and can prolong the QT interval, and aripiprazole adds sedation and a small QT liability. The combination increases the risk of drowsiness, impaired psychomotor performance and arrhythmia in susceptible patients.
What this interaction means in plain words
Aripiprazole and Hydroxyzine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Aripiprazole belongs to Central Nervous System; Hydroxyzine belongs to Respiratory.
Why it happens
Additive CNS depression via histamine H1 blockade and additive effects on cardiac repolarization.
What to do
Use the lowest effective hydroxyzine dose and warn about driving and sedation. Check an ECG and electrolytes in patients with QT risk factors.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Aripiprazole
- Aripiprazole + Pimozide Contraindicated
- Aripiprazole + Thioridazine Contraindicated
- Amisulpride + Aripiprazole Major
- Aripiprazole + Arsenic trioxide Major
- Aripiprazole + Calcium / magnesium / potassium / sodium oxybates Major
- Aripiprazole + Carbamazepine Major
Other interactions of Hydroxyzine
- Droperidol + Hydroxyzine Contraindicated
- Hydroxyzine + Pimozide Contraindicated
- Hydroxyzine + Thioridazine Contraindicated
- Hydroxyzine + Vandetanib Contraindicated
- Alfentanil + Hydroxyzine Major
- Amiodarone + Hydroxyzine Major
Frequently asked questions
Can I take Aripiprazole with Hydroxyzine?
MediHelp rates the interaction as moderate. Aripiprazole and Hydroxyzine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Hydroxyzine is sedating and can prolong the QT interval, and aripiprazole adds sedation and a small QT liability. The combination increases the risk of drowsiness, impaired psychomotor performance and arrhythmia in susceptible patients.
How serious is the interaction between Aripiprazole and Hydroxyzine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective hydroxyzine dose and warn about driving and sedation. Check an ECG and electrolytes in patients with QT risk factors.
What other medicines interact with Aripiprazole?
MediHelp also lists interactions of Aripiprazole with, for example, Pimozide, Thioridazine, Amisulpride. The full list is on the Aripiprazole page.
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