Drug interactions
Aripiprazole + Itraconazole
Severity: Major
Aripiprazole and Itraconazole: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Itraconazole inhibits CYP3A4 and raises aripiprazole exposure, which may cause akathisia, sedation and other dose-related effects. QT effects are minimal, so the concern is mainly pharmacokinetic.
What this interaction means in plain words
Aripiprazole and Itraconazole can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Aripiprazole belongs to Central Nervous System; Itraconazole belongs to Anti Fungals.
Why it happens
Strong CYP3A4 inhibition by itraconazole reduces aripiprazole clearance.
What to do
Reduce the aripiprazole dose to about half the usual dose during itraconazole use and monitor for adverse effects. Restore the dose after itraconazole is stopped.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Itraconazole
- Alfuzosin + Itraconazole Contraindicated
- Alprazolam + Itraconazole Contraindicated
- Avanafil + Itraconazole Contraindicated
- Conivaptan + Itraconazole Contraindicated
- Dihydroergotamine intranasal + Itraconazole Contraindicated
- Dihydroergotamine + Itraconazole Contraindicated
Other interactions of Aripiprazole
- Aripiprazole + Pimozide Contraindicated
- Aripiprazole + Thioridazine Contraindicated
- Amisulpride + Aripiprazole Major
- Aripiprazole + Arsenic trioxide Major
- Aripiprazole + Calcium / magnesium / potassium / sodium oxybates Major
- Aripiprazole + Carbamazepine Major
Frequently asked questions
Can I take Aripiprazole with Itraconazole?
MediHelp rates the interaction as major. Aripiprazole and Itraconazole can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Itraconazole inhibits CYP3A4 and raises aripiprazole exposure, which may cause akathisia, sedation and other dose-related effects. QT effects are minimal, so the concern is mainly pharmacokinetic.
How serious is the interaction between Aripiprazole and Itraconazole?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Reduce the aripiprazole dose to about half the usual dose during itraconazole use and monitor for adverse effects. Restore the dose after itraconazole is stopped.
What other medicines interact with Itraconazole?
MediHelp also lists interactions of Itraconazole with, for example, Alfuzosin, Alprazolam, Avanafil. The full list is on the Itraconazole page.
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