Drug interactions
Aripiprazole + Letermovir
Severity: Moderate
Aripiprazole and Letermovir: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Letermovir inhibits CYP3A4 in a moderate fashion and may increase aripiprazole concentrations. This raises the likelihood of dose-related adverse effects.
What this interaction means in plain words
Aripiprazole and Letermovir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Aripiprazole belongs to Central Nervous System; Letermovir belongs to Anti Virals.
Why it happens
Letermovir inhibits CYP3A4-mediated metabolism of aripiprazole.
What to do
Monitor for increased aripiprazole effects such as akathisia, sedation and hypotension, and lower the dose if they occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Aripiprazole
- Aripiprazole + Pimozide Contraindicated
- Aripiprazole + Thioridazine Contraindicated
- Amisulpride + Aripiprazole Major
- Aripiprazole + Arsenic trioxide Major
- Aripiprazole + Calcium / magnesium / potassium / sodium oxybates Major
- Aripiprazole + Carbamazepine Major
Other interactions of Letermovir
- Ergotamine + Letermovir Contraindicated
- Letermovir + Pimozide Contraindicated
- Apalutamide + Letermovir Major
- Atorvastatin + Letermovir Major
- Carbamazepine + Letermovir Major
- Colchicine + Letermovir Major
Frequently asked questions
Can I take Aripiprazole with Letermovir?
MediHelp rates the interaction as moderate. Aripiprazole and Letermovir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Letermovir inhibits CYP3A4 in a moderate fashion and may increase aripiprazole concentrations. This raises the likelihood of dose-related adverse effects.
How serious is the interaction between Aripiprazole and Letermovir?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for increased aripiprazole effects such as akathisia, sedation and hypotension, and lower the dose if they occur.
What other medicines interact with Aripiprazole?
MediHelp also lists interactions of Aripiprazole with, for example, Pimozide, Thioridazine, Amisulpride. The full list is on the Aripiprazole page.
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