Drug interactions
Aripiprazole + Lonafarnib
Severity: Major
Aripiprazole and Lonafarnib: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lonafarnib is a strong CYP3A inhibitor and can substantially raise levels of drugs cleared by CYP3A4, including aripiprazole. This may increase akathisia, sedation, and other adverse effects.
What this interaction means in plain words
Aripiprazole and Lonafarnib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Aripiprazole belongs to Central Nervous System; Lonafarnib belongs to Miscellaneous.
Why it happens
Strong CYP3A4 inhibition by lonafarnib reduces aripiprazole clearance.
What to do
Reduce the aripiprazole dose to about half while lonafarnib is given, and monitor for adverse effects. Restore the dose after lonafarnib is stopped.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Aripiprazole
- Aripiprazole + Pimozide Contraindicated
- Aripiprazole + Thioridazine Contraindicated
- Amisulpride + Aripiprazole Major
- Aripiprazole + Arsenic trioxide Major
- Aripiprazole + Calcium / magnesium / potassium / sodium oxybates Major
- Aripiprazole + Carbamazepine Major
Other interactions of Lonafarnib
- Alfuzosin + Lonafarnib Contraindicated
- Amobarbital + Lonafarnib Contraindicated
- Apalutamide + Lonafarnib Contraindicated
- Bosentan + Lonafarnib Contraindicated
- Carbamazepine + Lonafarnib Contraindicated
- Clarithromycin + Lonafarnib Contraindicated
Frequently asked questions
Can I take Aripiprazole with Lonafarnib?
MediHelp rates the interaction as major. Aripiprazole and Lonafarnib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Lonafarnib is a strong CYP3A inhibitor and can substantially raise levels of drugs cleared by CYP3A4, including aripiprazole. This may increase akathisia, sedation, and other adverse effects.
How serious is the interaction between Aripiprazole and Lonafarnib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Reduce the aripiprazole dose to about half while lonafarnib is given, and monitor for adverse effects. Restore the dose after lonafarnib is stopped.
What other medicines interact with Aripiprazole?
MediHelp also lists interactions of Aripiprazole with, for example, Pimozide, Thioridazine, Amisulpride. The full list is on the Aripiprazole page.
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