Drug interactions
Aripiprazole + Loperamide
Severity: Minor
Aripiprazole and Loperamide: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both agents have been linked to QT prolongation, though aripiprazole's effect is small. Combination may add modestly to arrhythmia risk, mainly with excessive loperamide doses.
What this interaction means in plain words
Aripiprazole and Loperamide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Aripiprazole belongs to Central Nervous System; Loperamide belongs to Gastrointestinal Tract.
Why it happens
Possible additive QT prolongation.
What to do
Use loperamide at labeled doses only. Check ECG if other QT risk factors are present.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Loperamide
Other interactions of Aripiprazole
- Aripiprazole + Pimozide Contraindicated
- Aripiprazole + Thioridazine Contraindicated
- Amisulpride + Aripiprazole Major
- Aripiprazole + Arsenic trioxide Major
- Aripiprazole + Calcium / magnesium / potassium / sodium oxybates Major
- Aripiprazole + Carbamazepine Major
Frequently asked questions
Can I take Aripiprazole with Loperamide?
MediHelp rates the interaction as minor. Aripiprazole and Loperamide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Both agents have been linked to QT prolongation, though aripiprazole's effect is small. Combination may add modestly to arrhythmia risk, mainly with excessive loperamide doses.
How serious is the interaction between Aripiprazole and Loperamide?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use loperamide at labeled doses only. Check ECG if other QT risk factors are present.
What other medicines interact with Loperamide?
MediHelp also lists interactions of Loperamide with, for example, Amiodarone, Amisulpride, Anagrelide. The full list is on the Loperamide page.
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