Drug interactions
Aripiprazole + Lurasidone
Severity: Moderate
Aripiprazole and Lurasidone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both are atypical antipsychotics, so combining them gives additive sedation, orthostatic hypotension, extrapyramidal effects and metabolic burden. Such combinations lack strong evidence of benefit.
What this interaction means in plain words
Aripiprazole and Lurasidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Aripiprazole belongs to Central Nervous System; Lurasidone belongs to Central Nervous System.
Why it happens
Additive dopamine and serotonin receptor antagonism and CNS depressant effects.
What to do
Avoid routine antipsychotic polypharmacy unless clearly justified. If used, monitor for sedation, extrapyramidal symptoms, and metabolic parameters.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Aripiprazole
- Aripiprazole + Pimozide Contraindicated
- Aripiprazole + Thioridazine Contraindicated
- Amisulpride + Aripiprazole Major
- Aripiprazole + Arsenic trioxide Major
- Aripiprazole + Calcium / magnesium / potassium / sodium oxybates Major
- Aripiprazole + Carbamazepine Major
Other interactions of Lurasidone
- Apalutamide + Lurasidone Contraindicated
- Atazanavir + Lurasidone Contraindicated
- Carbamazepine + Lurasidone Contraindicated
- Clarithromycin + Lurasidone Contraindicated
- Cobicistat + Lurasidone Contraindicated
- Conivaptan + Lurasidone Contraindicated
Frequently asked questions
Can I take Aripiprazole with Lurasidone?
MediHelp rates the interaction as moderate. Aripiprazole and Lurasidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both are atypical antipsychotics, so combining them gives additive sedation, orthostatic hypotension, extrapyramidal effects and metabolic burden. Such combinations lack strong evidence of benefit.
How serious is the interaction between Aripiprazole and Lurasidone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid routine antipsychotic polypharmacy unless clearly justified. If used, monitor for sedation, extrapyramidal symptoms, and metabolic parameters.
What other medicines interact with Aripiprazole?
MediHelp also lists interactions of Aripiprazole with, for example, Pimozide, Thioridazine, Amisulpride. The full list is on the Aripiprazole page.
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