Drug interactions
Aripiprazole + Mefloquine
Severity: Moderate
Aripiprazole and Mefloquine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Mefloquine can prolong the QT interval and aripiprazole has a small potential to do so, so the combination may add to arrhythmia risk. Mefloquine's neuropsychiatric effects may also complicate treatment of psychiatric patients.
What this interaction means in plain words
Aripiprazole and Mefloquine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Aripiprazole belongs to Central Nervous System; Mefloquine belongs to Anti Parasitic.
Why it happens
Possible additive QT prolongation; aripiprazole's effect is modest.
What to do
Obtain a baseline ECG and check electrolytes if the combination is needed. Consider another antimalarial in patients with psychiatric illness or cardiac risk factors.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Mefloquine
- Arsenic trioxide + Mefloquine Contraindicated
- Dronedarone + Mefloquine Contraindicated
- Ibutilide + Mefloquine Contraindicated
- Levoketoconazole + Mefloquine Contraindicated
- Mefloquine + Nilotinib Contraindicated
- Mefloquine + Pimozide Contraindicated
Other interactions of Aripiprazole
- Aripiprazole + Pimozide Contraindicated
- Aripiprazole + Thioridazine Contraindicated
- Amisulpride + Aripiprazole Major
- Aripiprazole + Arsenic trioxide Major
- Aripiprazole + Calcium / magnesium / potassium / sodium oxybates Major
- Aripiprazole + Carbamazepine Major
Frequently asked questions
Can I take Aripiprazole with Mefloquine?
MediHelp rates the interaction as moderate. Aripiprazole and Mefloquine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Mefloquine can prolong the QT interval and aripiprazole has a small potential to do so, so the combination may add to arrhythmia risk. Mefloquine's neuropsychiatric effects may also complicate treatment of psychiatric patients.
How serious is the interaction between Aripiprazole and Mefloquine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline ECG and check electrolytes if the combination is needed. Consider another antimalarial in patients with psychiatric illness or cardiac risk factors.
What other medicines interact with Mefloquine?
MediHelp also lists interactions of Mefloquine with, for example, Arsenic trioxide, Dronedarone, Ibutilide. The full list is on the Mefloquine page.
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