Drug interactions
Aripiprazole + Mirabegron
Severity: Minor
Aripiprazole and Mirabegron: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Mirabegron can inhibit CYP2D6, increasing exposure to aripiprazole, which is metabolized by CYP2D6 and CYP3A4. Increased akathisia, sedation or other adverse effects may occur.
What this interaction means in plain words
Aripiprazole and Mirabegron have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Aripiprazole belongs to Central Nervous System; Mirabegron belongs to Genitourinary.
Why it happens
Moderate CYP2D6 inhibition by mirabegron.
What to do
Monitor for akathisia, sedation and other adverse effects. Adjust the aripiprazole dose if these appear.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Aripiprazole and Mirabegron, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Mirabegron
- Digoxin + Mirabegron Major
- Flecainide + Mirabegron Major
- Mirabegron + Propafenone Major
- Mirabegron + Thioridazine Major
- Amitriptyline + Mirabegron Moderate
- Amoxapine + Mirabegron Moderate
Other interactions of Aripiprazole
- Aripiprazole + Pimozide Contraindicated
- Aripiprazole + Thioridazine Contraindicated
- Amisulpride + Aripiprazole Major
- Aripiprazole + Arsenic trioxide Major
- Aripiprazole + Calcium / magnesium / potassium / sodium oxybates Major
- Aripiprazole + Carbamazepine Major
Frequently asked questions
Can I take Aripiprazole with Mirabegron?
MediHelp rates the interaction as minor. Aripiprazole and Mirabegron have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Mirabegron can inhibit CYP2D6, increasing exposure to aripiprazole, which is metabolized by CYP2D6 and CYP3A4. Increased akathisia, sedation or other adverse effects may occur.
How serious is the interaction between Aripiprazole and Mirabegron?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for akathisia, sedation and other adverse effects. Adjust the aripiprazole dose if these appear.
What other medicines interact with Mirabegron?
MediHelp also lists interactions of Mirabegron with, for example, Digoxin, Flecainide, Propafenone. The full list is on the Mirabegron page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
