Drug interactions
Aripiprazole + Nabilone
Severity: Moderate
Aripiprazole and Nabilone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can cause drowsiness and impaired psychomotor performance, so taking them together may produce more sedation than either alone. Nabilone can also cause dizziness and orthostatic effects that may add to those of the antipsychotic.
What this interaction means in plain words
Aripiprazole and Nabilone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Aripiprazole belongs to Central Nervous System; Nabilone belongs to Gastrointestinal Tract.
Why it happens
Additive central nervous system depression through pharmacodynamic synergy.
What to do
Start nabilone at the lowest dose and monitor for excessive sedation, dizziness and impaired alertness. Advise patients to avoid driving and alcohol until the response is known.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Nabilone
Other interactions of Aripiprazole
- Aripiprazole + Pimozide Contraindicated
- Aripiprazole + Thioridazine Contraindicated
- Amisulpride + Aripiprazole Major
- Aripiprazole + Arsenic trioxide Major
- Aripiprazole + Calcium / magnesium / potassium / sodium oxybates Major
- Aripiprazole + Carbamazepine Major
Frequently asked questions
Can I take Aripiprazole with Nabilone?
MediHelp rates the interaction as moderate. Aripiprazole and Nabilone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs can cause drowsiness and impaired psychomotor performance, so taking them together may produce more sedation than either alone. Nabilone can also cause dizziness and orthostatic effects that may add to those of the antipsychotic.
How serious is the interaction between Aripiprazole and Nabilone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Start nabilone at the lowest dose and monitor for excessive sedation, dizziness and impaired alertness. Advise patients to avoid driving and alcohol until the response is known.
What other medicines interact with Nabilone?
MediHelp also lists interactions of Nabilone with, for example, Alfentanil, Amobarbital, Belladonna and opium. The full list is on the Nabilone page.
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