Drug interactions
Aripiprazole + Oxaliplatin
Severity: Moderate
Aripiprazole and Oxaliplatin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Oxaliplatin has been linked to QT prolongation and torsades de pointes, often aggravated by electrolyte loss from chemotherapy. Aripiprazole may add slightly to this risk.
What this interaction means in plain words
Aripiprazole and Oxaliplatin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Aripiprazole belongs to Central Nervous System; Oxaliplatin belongs to Oncology.
Why it happens
Additive pharmacodynamic effect on cardiac repolarization.
What to do
Check ECG and correct potassium, magnesium and calcium before each oxaliplatin cycle. Monitor ECG if other QT-prolonging drugs or risk factors are present.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Aripiprazole
- Aripiprazole + Pimozide Contraindicated
- Aripiprazole + Thioridazine Contraindicated
- Amisulpride + Aripiprazole Major
- Aripiprazole + Arsenic trioxide Major
- Aripiprazole + Calcium / magnesium / potassium / sodium oxybates Major
- Aripiprazole + Carbamazepine Major
Other interactions of Oxaliplatin
- Adenovirus types 4 and 7 live + Oxaliplatin Contraindicated
- Bcg vaccine live + Oxaliplatin Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Oxaliplatin Contraindicated
- Measles mumps and rubella vaccine live + Oxaliplatin Contraindicated
- Measles mumps and rubella vaccine + Oxaliplatin Contraindicated
- Measles mumps rubella and varicella vaccine live + Oxaliplatin Contraindicated
Frequently asked questions
Can I take Aripiprazole with Oxaliplatin?
MediHelp rates the interaction as moderate. Aripiprazole and Oxaliplatin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Oxaliplatin has been linked to QT prolongation and torsades de pointes, often aggravated by electrolyte loss from chemotherapy. Aripiprazole may add slightly to this risk.
How serious is the interaction between Aripiprazole and Oxaliplatin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check ECG and correct potassium, magnesium and calcium before each oxaliplatin cycle. Monitor ECG if other QT-prolonging drugs or risk factors are present.
What other medicines interact with Aripiprazole?
MediHelp also lists interactions of Aripiprazole with, for example, Pimozide, Thioridazine, Amisulpride. The full list is on the Aripiprazole page.
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