Drug interactions
Aripiprazole + Paliperidone
Severity: Moderate
Aripiprazole and Paliperidone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Paliperidone prolongs the QT interval and aripiprazole has a small effect, so combined use may modestly increase arrhythmia risk. Using two antipsychotics also adds to the burden of adverse effects such as sedation and extrapyramidal symptoms.
What this interaction means in plain words
Aripiprazole and Paliperidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Aripiprazole belongs to Central Nervous System; Paliperidone belongs to Central Nervous System.
Why it happens
Additive pharmacodynamic QTc prolongation and overlapping dopamine receptor effects.
What to do
Obtain a baseline ECG and keep potassium and magnesium normal. Monitor for QT-related symptoms and review the need for dual antipsychotic therapy.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Aripiprazole
- Aripiprazole + Pimozide Contraindicated
- Aripiprazole + Thioridazine Contraindicated
- Amisulpride + Aripiprazole Major
- Aripiprazole + Arsenic trioxide Major
- Aripiprazole + Calcium / magnesium / potassium / sodium oxybates Major
- Aripiprazole + Carbamazepine Major
Other interactions of Paliperidone
- Ibutilide + Paliperidone Contraindicated
- Paliperidone + Pimozide Contraindicated
- Paliperidone + Vandetanib Contraindicated
- Adagrasib + Paliperidone Major
- Amiodarone + Paliperidone Major
- Amisulpride + Paliperidone Major
Frequently asked questions
Can I take Aripiprazole with Paliperidone?
MediHelp rates the interaction as moderate. Aripiprazole and Paliperidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Paliperidone prolongs the QT interval and aripiprazole has a small effect, so combined use may modestly increase arrhythmia risk. Using two antipsychotics also adds to the burden of adverse effects such as sedation and extrapyramidal symptoms.
How serious is the interaction between Aripiprazole and Paliperidone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline ECG and keep potassium and magnesium normal. Monitor for QT-related symptoms and review the need for dual antipsychotic therapy.
What other medicines interact with Aripiprazole?
MediHelp also lists interactions of Aripiprazole with, for example, Pimozide, Thioridazine, Amisulpride. The full list is on the Aripiprazole page.
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